CAS 73-78-9 Lidocaine hydrochloride

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    Common Name Lidocaine hydrochloride
    CAS Number 73-78-9 Molecular Weight 270.798
    Density N/A Boiling Point 350.8ºC at 760 mmHg
    Molecular Formula C14H23ClN2O Melting Point 80-82°C
    MSDS N/A Flash Point 166ºC
    PACKING (9)
    PACKING (8)

    Use of Lidocaine hydrochloride

    Lidocaine Hcl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.Target: Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Lidocaine, the first amino amide–type local anesthetic, was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. His colleague Bengt Lundqvist performed the first injection anesthesia experiments on himself.Lidocaine is approximately 95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide (MEGX) and then subsequently to the inactive glycine xylidide. MEGX has a longer half life than lidocaine but also is a less potent sodium channel blocker. The elimination half-life of lidocaine is approximately 90–120 minutes in most patients. This may be prolonged in patients with hepatic impairment (average 343 minutes) or congestive heart failure (average 136 minutes).


    N-(2,6-Dimethylphenyl)-N,N-diethylglycinamide hydrochloride (1:1)
    (Diethylamino)-2',6'-acetoxylidide Monohydrochloride
    2-(diéthylamino)-N-(2,6-diméthylphényl)acétamide chlorhydrate
    Xilina hydrochloride
    2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide, hydrochloride (1:1)
    N-(2,6-dimethylphenyl)-N,N-diethylglycinamide hydrochloride
    Lidocaine hydrochloride
    lignocaine hydrochloride
    2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide monohydrochloride
    Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)
    N-(2,6-dimethylphenyl)-N2,N2-diethylglycinamide hydrochloride
    2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride
    EINECS 200-803-8
    2',6'-Acetoxylidide, 2-(diethylamino)-, monohydrochloride (8CI)
    2N2&1VMR B1 F1 &&HCl
    Lidocaine (hydrochloride)

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